Article 1
Pages 1–11
Prediction of Long-Term Health-Related Quality of Life after Bariatric Surgery Using a Conventional Neural Network: Data from the Scandinavian Obesity Surgery Registry
Yang Cao, Mustafa Raoof, Scott Montgomery, Johan Ottosson, and Ingmar Näslund
Severe obesity has been associated with numerous comorbidities and reduced health-related quality of life (HRQoL).
This study evaluated a conventional neural network model for predicting 5-year HRQoL after bariatric surgery using
preoperative information from the Scandinavian Obesity Surgery Registry. The model outperformed conventional linear
regression in the test dataset, although overfitting remained a concern.
Article 2
Pages 12–22
Detection of Insulin Resistance-Associated Cognitive Impairment in Morbid Obesity Using Retinal Microperimetry
Andreea Ciudin, Angel Michael Ortiz-Zuñiga, Enzamaria Fidilio, Diana Romero, Marta Sánchez, Marta Comas, Oscar Gonzalez, Ramon Vilallonga, Olga Simó-Servat, Cristina Hernández, and Rafael Simó
This pilot study explored cognitive impairment in morbid obesity and assessed whether retinal microperimetry could help identify affected patients.
The findings suggested that systemic insulin resistance may play a major role in cognitive decline and that retinal microperimetry may serve
as a useful, noninvasive screening tool.
Article 3
Pages 23–33
Emergency Department Evidence on Type 1 and Type 2 Myocardial Infarction in Patients with a History of Coronary Artery Disease
Alain Putot, Mélanie Jeanmichel, Frédéric Chagué, Aurélie Avondo, Patrick Ray, Patrick Manckoundia, Marianne Zeller, and Yves Cottin
This study examined the incidence and characteristics of type 1 and type 2 myocardial infarction in emergency department patients with known
coronary artery disease. The results showed that prior coronary artery disease was associated with a higher likelihood of type 2 myocardial infarction,
along with higher in-hospital mortality and distinct biomarker patterns.
Article 4
Pages 34–40
Laser Versus Monopolar Electrocautery in Transoral Robot-Assisted Surgery for Supraglottic and Oropharyngeal Squamous Cell Carcinoma
Marco Benazzo, Pietro Canzi, Simone Mauramati, Fabio Sovardi, Antonio Occhini, Eugenia Maiorano, Giuseppe Trisolini, and Patrizia Morbini
This retrospective comparison assessed laser-TORS and electrocautery-TORS in patients with supraglottic and oropharyngeal squamous cell carcinoma.
Laser-based surgery demonstrated more favorable tumour margin status and better postoperative functional recovery, although larger prospective
studies are still needed.
Article 5
Pages 41–52
Relationship Between High-Sensitivity C-Reactive Protein and Acute Kidney Injury in Acute Myocardial Infarction Patients: A Prospective Observational Study
Nicola Cosentino, Stefano Genovese, Jeness Campodonico, Alice Bonomi, Claudia Lucci, Valentina Milazzo, Marco Moltrasio, Maria Luisa Biondi, Daniela Riggio, Fabrizio Veglia, Roberto Ceriani, Katia Celentano, Monica De Metrio, Mara Rubino, Antonio L. Bartorelli, and Giancarlo Marenzi
In this prospective observational study of acute myocardial infarction patients, admission hs-CRP was closely associated with acute kidney injury
incidence, severity, and adverse in-hospital outcomes. The study supports hs-CRP as a potentially useful marker for early renal risk stratification in AMI.
Article 6
Pages 53–61
Chronic Kidney Disease Three Years after Non-Severe Acute Kidney Injury in Critically Ill Patients: A Single-Center Cohort Study
Edouard Fortrie, Hugo J.C.M. de Geus, Olivier Misset, H. Bas Binnekade, Arthur H.J. Danser, Anton H. van den Meiracker, and Jos F. Frencken
This single-center cohort study evaluated the long-term renal consequences of non-severe acute kidney injury in critically ill patients.
The results indicated that even non-severe AKI may be associated with an increased risk of chronic kidney disease after three years.
Article 7
Pages 62–72
Association of Neopterin with Disease Severity and Clinical Outcomes in Patients with Non-Ischaemic Heart Failure
Lukas Lanser, Gerhard Pölzl, Dietmar Fuchs, Günter Weiss, and Katharina Kurz
This study investigated inflammatory biomarkers in patients with non-ischaemic heart failure and found that neopterin was associated with disease
severity and prognosis. Higher neopterin levels independently predicted adverse clinical outcomes, suggesting value in risk assessment.
Article 8
Pages 73–80
Prefrontal Cortex Oxygenation during Memory Interference: An Assessment
Lindsay Crawford, Liye Zou, and Paul D. Loprinzi
This study assessed whether prefrontal cortex oxygenation was associated with proactive and retroactive memory interference in humans.
The findings provided evidence supporting the null hypothesis, indicating no clear association in this sample.
Article 9
Pages 81–95
The Role of Hemoglobin Electrophoresis in Evaluating Engraftment Following Allogeneic Hematopoietic Stem Cell Transplantation in Homozygous Hemoglobin S Disease
Asmaa Morjan, Manzama-Esso Kassang Konzi, Youssef Bamou, and Lhoussine Balouch
This case study evaluated the contribution of hemoglobin electrophoresis in monitoring engraftment after allogeneic hematopoietic stem cell transplantation in a patient with severe homozygous hemoglobin S disease. Hemoglobin S decreased from 80.4% before transplantation to 4.9% eight weeks after transplantation, alongside mixed chimerism of 58.74% and near-complete clinical remission. The findings support hemoglobin electrophoresis as a reliable tool for assessing engraftment and detecting graft rejection when post-transplant transfusions do not interfere with measured hemoglobin fractions.
Article 10
Pages 96–101
Use of Buprenorphine in Palliative Care
Laure Gazaigne, Roger Thay, Laure Copel, Stéphane Picard, and Ingrid Joffin
This article presents two clinical case reports examining the use of buprenorphine in palliative care for patients receiving long-term opioid substitution therapy. The authors discuss the challenges associated with discontinuing buprenorphine, review current evidence regarding pain management, and suggest that continuing buprenorphine alongside appropriate analgesic therapy may provide better symptom control while reducing withdrawal-related complications in palliative care patients.